Why Do My Lips Itch, Flake, and Swell? Q&A (2025)

Hello! I'm Dr. ******, a medical expert with over 40 years of experience in the U.S. I understand you're experiencing some issues with your lips. Could you please describe what's been happening?

Customer

Good morning! Yes, I've been having this problem on and off. My lips get itchy and sometimes swell. I've tried various lip balms and lipsticks, but nothing seems to help. There are also painful, tiny wounds on the sides of my lips, and the color is changing. Spicy foods and flavored toothpaste seem to trigger it as well.

I see. It sounds quite uncomfortable. Have you been using anything like hydrocortisone for relief?

Customer

Yes, I used hydrocortisone for a while, and it helped temporarily, but the issue keeps coming back. I'm not sure what triggers it or how to prevent it because it's very uncomfortable.

Absolutely, I understand your concern. Could you send me a couple of pictures of the affected area? Just gently open your mouth so I can see the corners.

Customer

Sure, I can do that.

Great! I will send you a message prompting you to attach those pictures. Once I receive them, I'll be able to provide more specific advice.

Customer

Okay, I received the message and attached the pictures.

Thank you for sending those. I can see the issue you're describing. This condition is known as angular stomatitis. It often occurs in the creases where the lips meet, especially if the skin breaks down. Yeast can invade these areas, causing further irritation. It's important to avoid using hydrocortisone or any triple antibiotic ointments, as they can exacerbate the problem by feeding the fungus.

Customer

Okay, I understand. I’m currently taking **** due to my mechanical valves, but everything has been fine with that.

That's good to hear. How long have you been on ****?

Customer

It's been almost two years now, and I take multivitamins daily as well.

Excellent. Just make sure to monitor your INR levels and follow any dietary restrictions. Now, let’s focus on treating your lips. Please stop using hydrocortisone immediately. Instead, I recommend you get Desitin ointment and Lotrimin cream. You can mix them in equal parts and apply the mixture to the affected areas three times a day. This combination is soothing and helps retain moisture, preventing further skin breakdown.

Customer

Got it. Should I apply this around my lips as well since my upper lip is flaky and dry?

Yes, absolutely. You can apply it around your lips. Additionally, if the itching is bothersome, consider taking a generic Zyrtec tablet at bedtime. It can help with the itching and swelling, and it may cause some drowsiness, so it's best taken at night.

Customer

Okay, that sounds good. What time is it there? I'm in ****, and it's 11:53 AM here.

It's 10:23 AM here in Eastern Time. I’ll keep track of your progress through text chat and check in with you in the coming days. This condition is common, and I believe we can achieve quick relief and healing within a few days.

Customer

That’s reassuring to know. Can I still wear lipstick while using the ointment?

Of course! Just opt for a plain, non-flavored lipstick and avoid any flavored ones for now. Also, try to refrain from opening your mouth too wide until everything heals.

Customer

Alright, thank you for all the information. I’ll get the ointments and keep you updated on my progress.

You're very welcome! I hope you have a wonderful day. Take care!

Customer

You too! Thank you again.

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